MRI-guided focused ultrasound systems exist that can, in principle, deliver the ultrasound protocol we successfully tested here. In addition, MRI, as the clinical gold standard, can readily identify MS lesions. Given the relatively low intensity values of our ultrasound protocol - close to FDA limits - we anticipate that future success with this approach to MS therapy as tested using more realistic MS mouse models may one day translate to clinical trials that help address this devastating disease.
Keyphrases
- multiple sclerosis
- mouse model
- magnetic resonance imaging
- mass spectrometry
- white matter
- clinical trial
- ms ms
- contrast enhanced
- randomized controlled trial
- diffusion weighted imaging
- computed tomography
- ultrasound guided
- magnetic resonance
- current status
- stem cells
- resting state
- study protocol
- phase ii
- bone marrow
- cell therapy
- smoking cessation