A novel yeast-based screening system for potential compounds that can alleviate human α-synuclein toxicity.

Anyaporn SangkaewThanaporn KojornnaRyoya TanahashiHiroshi Takagi Chulee Yompakdee

Published in: Journal of applied microbiology (2021)

Yeast-based assay system can be used to discover novel neuroprotective drug candidates which may be either efficiently suppress-α-syn aggregation or enhance ubiquitin-dependent degradation.

Keyphrases

saccharomyces cerevisiae
endothelial cells
cell wall
high throughput
induced pluripotent stem cells
oxidative stress
pluripotent stem cells
brain injury
single cell