Association between CD47 expression, clinical characteristics and prognosis in patients with advanced non-small cell lung cancer.

Arrieta OscarAlejandro Aviles-SalasMario Orozco-MoralesNorma Hernández-PedroAndrés Felipe CardonaLuis Cabrera-MirandaPedro Barrios-BernalGiovanny Soca-ChafreGraciela Cruz-RicoMaría de Lourdes Peña-TorresGuadalupe Moncada-ClaudioLaura-Alejandra Ramirez-Tirado

Published in: Cancer medicine (2020)

CD47 overexpression is not a prognostic factor for PFS and OS in NSCLC patients. However, the presence of EGFR mutations and high expression of CD47 were associated with shortened PFS and OS. Coexpression of these markers represents a potential biomarker and characterizes a therapeutic niche for lung cancer.

Keyphrases

prognostic factors
advanced non small cell lung cancer
epidermal growth factor receptor
small cell lung cancer
poor prognosis
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
tyrosine kinase
cell proliferation
peritoneal dialysis
binding protein