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Circulating matrix metalloproteinases and tissue metalloproteinase inhibitors in patients with idiopathic pulmonary fibrosis in the multicenter IPF-PRO Registry cohort.

Jamie L ToddRichard ViniskoYi LiuMegan L NeelyRobert OvertonKevin R FlahertyImre NothL Kristin NewbyJoseph A LaskyMitchell A OlmanChristian HesslingerThomas B LeonardScott M PalmerJohn A Belperionull null
Published in: BMC pulmonary medicine (2020)
Circulating MMPs and TIMPs were broadly elevated among patients with IPF. Select MMP/TIMPs strongly associated with measures of disease severity. Our results identify potential MMP/TIMP targets for further development as disease-related biomarkers.
Keyphrases
  • idiopathic pulmonary fibrosis
  • interstitial lung disease
  • cell migration
  • cross sectional
  • anti inflammatory
  • clinical trial
  • rheumatoid arthritis
  • risk assessment