Circulating matrix metalloproteinases and tissue metalloproteinase inhibitors in patients with idiopathic pulmonary fibrosis in the multicenter IPF-PRO Registry cohort.

Jamie L ToddRichard ViniskoYi LiuMegan L NeelyRobert OvertonKevin R FlahertyImre NothL Kristin NewbyJoseph A LaskyMitchell A OlmanChristian HesslingerThomas B LeonardScott M PalmerJohn A Belperionull null

Published in: BMC pulmonary medicine (2020)

Circulating MMPs and TIMPs were broadly elevated among patients with IPF. Select MMP/TIMPs strongly associated with measures of disease severity. Our results identify potential MMP/TIMP targets for further development as disease-related biomarkers.

Keyphrases

idiopathic pulmonary fibrosis
interstitial lung disease
cell migration
cross sectional
anti inflammatory
clinical trial
rheumatoid arthritis
risk assessment