Antagonizing apolipoprotein J chaperone promotes proteasomal degradation of mTOR and relieves hepatic lipid deposition.

Shuangdi Duan Nong Qin Jiayi Pi Pei Sun Yating Gao Lamei Liu Zenghui Li Ya LiLiyang ShiQiang GaoYe QiuSongqing TangChun-Hsiang WangTzu-Ying ChenSin-Tian WangKung-Chia Young Hung-Yu Sun

Published in: Hepatology (Baltimore, Md.) (2023)

ApoJ antagonist peptide might be a potential therapeutic against lipid-associated metabolic disorders through restoring mTOR and FBW7 interaction and facilitating ubiquitin-proteasomal degradation of mTOR.

Keyphrases

cell proliferation
fatty acid
small molecule
heat shock protein
oxidative stress