Endometrial scratching in women undergoing IVF/ICSI: an individual participant data meta-analysis.
Nienke E van HoogenhuijzeGemma Lahoz CasarramonaSarah LensenCindy FarquharMohan S KamathAleyamma T KunjummenNick Raine-FenningSine BerntsenAnja PinborgShari MackensZeynep Ozturk InalErnest Hung Yu NgJennifer S M MakSachin A NarvekarWellington P MartinsMia Steengaard OlesenHelen L TorranceBen-Willem J MolMarinus J C EijkemansRui WangFrank J M BroekmansPublished in: Human reproduction update (2023)
This is the first meta-analysis based on IPD of more than 4000 participants, and it demonstrates that endometrial scratching may improve LB rates in women undergoing IVF/ICSI. Subgroup analysis for age, number of previous failed embryo transfers, treatment type, and infertility cause could not identify subgroups in which endometrial scratching performed better or worse. The timing of endometrial scratching may play a role in its effectiveness. The use of endometrial scratching in clinical practice should be considered with caution, meaning that patients should be properly counseled on the level of evidence and the uncertainties.
Keyphrases
- pregnancy outcomes
- systematic review
- endometrial cancer
- polycystic ovary syndrome
- pregnant women
- end stage renal disease
- clinical practice
- meta analyses
- chronic kidney disease
- randomized controlled trial
- ejection fraction
- clinical trial
- insulin resistance
- patient reported outcomes
- machine learning
- artificial intelligence
- phase iii
- case control
- skeletal muscle
- type diabetes
- adipose tissue
- breast cancer risk