Tolerability of ifosfamide-containing regimen in patients with high-risk renal and INI-1-deficient tumors.

Chris I Wong Daniel J BenedettiPei-Chi KaoClement MaKaren J MarcusElizabeth A Mullen

Published in: Pediatric blood & cancer (2023)

In children with HRR/INI- tumors, VDC-ICE chemotherapy was well-tolerated without excessive toxicities, even amongst young patients with solitary kidneys. Concerns about toxicity should not preclude an intensive ifosfamide-containing regimen from use in future trials in this population.

Keyphrases

young adults
oxidative stress
current status
open label
weight gain
squamous cell carcinoma
body mass index
randomized controlled trial
clinical trial
radiation therapy
placebo controlled