Single-dose pharmacokinetics of co-crystal of tramadol-celecoxib: Results of a four-way randomized open-label phase I clinical trial in healthy subjects.

Sebastián VidelaMounia LahjouAnna VaquéMariano SustMercedes EncaboLluis SolerArtur SansEric SicardNeus GascónGregorio EncinaCarlos Plata-Salamán

Published in: British journal of clinical pharmacology (2017)

PK parameters of each API in CTC were modified by co-crystallization compared with marketed formulations of tramadol, celecoxib, and their open combination.

Keyphrases

open label
clinical trial
phase ii
phase iii
double blind
phase ii study
study protocol
minimally invasive
circulating tumor cells
placebo controlled
squamous cell carcinoma
randomized controlled trial
circulating tumor
radiation therapy