Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner.
Peter W T LeeTatsuya SuwaMinoru KobayashiHui YangLina R KosekiSatoshi TakeuchiChristalle C T ChowTakaaki YasuharaHiroshi HaradaPublished in: British journal of cancer (2024)
These results together provide insights into a potential molecular mechanism of the acquisition of invasiveness by hypoxic cancer cells after radiotherapy via the activation of the ROS/HIF/HMHA1 axis.
Keyphrases
- endothelial cells
- high glucose
- papillary thyroid
- poor prognosis
- early stage
- diabetic rats
- squamous cell
- cell death
- dna damage
- radiation therapy
- locally advanced
- reactive oxygen species
- induced apoptosis
- drug induced
- radiation induced
- lymph node metastasis
- oxidative stress
- long non coding rna
- childhood cancer
- young adults
- risk assessment
- signaling pathway