Interferons Dominate Damage and Activity in Juvenile Scleroderma.
Hulya KoseAbdurrahman SimsekMuhammed Ali KizmazTugce BozkurtFerdi OzturkSukru CekicFerah BudakHayriye SarıcaogluSara Sebnem KilicPublished in: Modern rheumatology (2024)
The results suggest that interferon signaling may be impaired in patients with juvenile scleroderma. Significant changes were observed in cytokines and genes related to IFN signaling, which may have a crucial role in monitoring disease activity. In addition, we have gained important insights into the possibility of using IFN-α and IFN-γ as biomarkers for monitoring juvenile scleroderma activity and damage.
Keyphrases
- disease activity
- systemic sclerosis
- dendritic cells
- rheumatoid arthritis
- interstitial lung disease
- systemic lupus erythematosus
- immune response
- rheumatoid arthritis patients
- ankylosing spondylitis
- oxidative stress
- juvenile idiopathic arthritis
- genome wide
- gene expression
- idiopathic pulmonary fibrosis
- dna methylation
- drug induced