Effect of Curcumin Plus Piperine on Redox Imbalance, Fecal Calprotectin and Cytokine Levels in Inflammatory Bowel Disease Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Amylly Sanuelly da Paz MartinsOrlando Roberto Pimentel de AraújoAmanda da Silva GomesFernanda Lívia Cavalcante AraujoJosé Oliveira JuniorJoice Kelly Gomes de VasconcelosJosé Israel Rodrigues JuniorIslany Thaissa CerqueiraManoel Álvaro de Freitas Lins NetoNassib Bezerra BuenoMarília Oliveira Fonseca GoulartFabiana Andréa MouraPublished in: Pharmaceuticals (Basel, Switzerland) (2024)
In patients with inflammatory bowel disease (IBD), our study indicates that a 12-week curcumin plus piperine treatment effectively increases enzymatic antioxidant defense, especially SOD. These results demonstrate the potential therapeutic benefits of managing redox imbalance in individuals with IBD.
Keyphrases
- placebo controlled
- double blind
- clinical trial
- patients with inflammatory bowel disease
- phase ii
- end stage renal disease
- study protocol
- phase iii
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- randomized controlled trial
- open label
- phase ii study
- ulcerative colitis
- squamous cell carcinoma
- nitric oxide
- disease activity
- patient reported outcomes
- amyotrophic lateral sclerosis