Zuo Gui Wan Alters Expression of Energy Metabolism Genes and Prevents Cell Death in High-Glucose Loaded Mouse Embryos.
Qi LiangZhipeng QuYu LiangQianJin FengXin NiuTemaka BaiYingli WangQiang SongDavid L AdelsonPublished in: Evidence-based complementary and alternative medicine : eCAM (2018)
ZGW had a protective effect on embryonic cell death caused by glucose loading. The reversion of inhibition of ribosome pathway and regulation of mitochondrial energy metabolism are main effects of ZGW on high-glucose loaded embryos. This research not only revealed the global gene regulation changes of high glucose affecting 2-cell stage embryos but also provided insight into the potential molecular mechanisms of ZGW on the IGT model.
Keyphrases
- high glucose
- cell death
- endothelial cells
- drug delivery
- single cell
- cell cycle arrest
- poor prognosis
- cancer therapy
- oxidative stress
- genome wide
- cell therapy
- blood glucose
- gene expression
- binding protein
- metabolic syndrome
- blood pressure
- stem cells
- risk assessment
- adipose tissue
- human health
- skeletal muscle
- insulin resistance
- cell proliferation
- bioinformatics analysis
- genome wide analysis