Accounting for twin births in sample size calculations for randomised trials.

Lisa N YellandThomas R SullivanCarmel T CollinsDavid J PriceAndrew J McPheeKatherine J Lee

Published in: Paediatric and perinatal epidemiology (2018)

Clustering among outcomes measured on twins should be taken into account in sample size calculations to obtain the desired power. Our ICC estimates and sample size calculator will be useful for designing future trials that include twins. Publication of additional ICCs is needed to further assist with sample size planning for future trials.

Keyphrases

density functional theory
clinical trial
molecular dynamics
gestational age
current status
molecular dynamics simulations
type diabetes
randomized controlled trial
single cell
double blind
skeletal muscle
insulin resistance
monte carlo
preterm birth
glycemic control