Revolutionizing Daptomycin Dosing: A Single 7-11 Hour Sample for Pragmatic Application.
Jacopo AngeliniShuhan LiuSimone GuilianoSarah FlamminiLuca MartiniCarlo TasciniMassimo BaraldoManjunath Amit P PaiPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)
Precision daptomycin dosing faces clinical implementation barriers despite known exposure-safety concerns with the use of twice the regulatory-approved doses. We propose achieving a single 7-11 hour post-dose plasma target concentration of 30 mg/L to 43 mg/L to be a practical starting point to facilitate precision daptomycin dosing.