Engineered Exosomes with Growth Differentiation Factor-15 Overexpression Enhance Cardiac Repair After Myocardial Injury.
Ailin ZouTingting XiaoBoyu ChiYu WangLipeng MaoDabei CaiQingqing GuQianwen ChenQingjie WangYuan JiLing SunPublished in: International journal of nanomedicine (2024)
GDF15-EVs could fulfil their protective effects against myocardial injury by upregulating the expression of TERT and activating the AMPK signaling pathway. GDF15-EVs might be exploited to design new therapies for AMI.
Keyphrases
- signaling pathway
- left ventricular
- poor prognosis
- acute myocardial infarction
- pi k akt
- mesenchymal stem cells
- epithelial mesenchymal transition
- induced apoptosis
- stem cells
- cell proliferation
- skeletal muscle
- transcription factor
- binding protein
- heart failure
- long non coding rna
- protein kinase
- bone marrow
- oxidative stress