Four Meroterpenoids with Novel Aminoglycoside Moiety from the Basidiomycete Clitocybe clavipes with Cytotoxic Activity.
Zhonghao SunYongben MaJiawen ZhangGuoxu MaHaifeng WuLeiling ShiZhaocui SunXudong XuPublished in: Molecules (Basel, Switzerland) (2023)
Four new meroterpenoids, Clavilactone M-P, possessing novel aminoglycoside moiety ( 1 - 4 ) and a 10-membered carbocycle fused with an α,β-epoxy-γ-lactone, were isolated from Clitocybe clavipes , a basidiomycete. Their structures with absolute configurations were determined by extensive analysis of their spectroscopic data, and the ECD method. All the isolated compounds ( 1 - 4 ) were evaluated for their antitumor activity against three human cancer cell lines using the MTT assay. Compound 1 and 2 exhibited a significant suppression of cell viability in the Hela (IC 50 = 22.8 and 19.7 μM) cell line.
Keyphrases
- pseudomonas aeruginosa
- endothelial cells
- papillary thyroid
- acinetobacter baumannii
- molecular docking
- electronic health record
- high throughput
- squamous cell
- induced pluripotent stem cells
- high resolution
- pluripotent stem cells
- big data
- squamous cell carcinoma
- childhood cancer
- cell death
- signaling pathway
- cell cycle arrest
- data analysis