The left atrial appendage closure by surgery 2 trial: statistical analysis plan for a randomized multicenter trial exploring if the closure of the left atrial appendage during open-heart surgery reduces stroke irrespective of patients' stroke risk and preoperative atrial fibrillation status.
Christoffer Valdorff MadsenJesper Park-HansenRakin HadadAnders M GreveHelena DomínguezPublished in: Trials (2024)
https://doi.org/10.1016/j.ahj.2023.06.003 .
Keyphrases
- left atrial appendage
- atrial fibrillation
- minimally invasive
- catheter ablation
- oral anticoagulants
- left atrial
- direct oral anticoagulants
- coronary artery bypass
- end stage renal disease
- heart failure
- percutaneous coronary intervention
- phase iii
- study protocol
- ejection fraction
- clinical trial
- newly diagnosed
- chronic kidney disease
- phase ii
- peritoneal dialysis
- prognostic factors
- coronary artery disease
- cross sectional
- open label
- mitral valve
- venous thromboembolism
- placebo controlled