Transcriptomics of cumulus cells - a window into oocyte maturation in humans.

Brandon A WyseNoga Fuchs WeizmanSeth KadishHanna BalakierMugundhine SangaralingamClifford L Librach

Published in: Journal of ovarian research (2020)

Herein we review our findings and discuss how they align with previous literature addressing transcriptomic signatures of oocyte maturation. Our findings support the available literature and enhance it with several genes and pathways, which have not been previously implicated in promoting human oocyte maturation. This study lays the ground for future functional studies that can enhance our understanding of human oocyte maturation.

Keyphrases

endothelial cells
systematic review
single cell
induced pluripotent stem cells
genome wide
pluripotent stem cells
cell cycle arrest
cell proliferation
endoplasmic reticulum stress
case control
genome wide analysis