CuCl 2 ·2H 2 O/TBHP mediated synthesis of β-enaminones via coupling reaction of vinyl azides with aldehydes.

A facile and efficient oxidative functionalization of vinyl azides with aldehydes furnishing a diverse array of β-acylated enaminones was developed. The cross coupling was accomplished in the presence of CuCl 2 ·2H 2 O/TBHP and produced the desired β-acylated enaminones in a ( Z )-stereo-selective and atom-economic manner, which make this protocol particularly attractive. In the transformation, the new C-C and C-N bonds were formed via a one-pot strategy including the process of radical addition and recombination.