Enkurin: A novel marker for myeloproliferative neoplasms from platelet, megakaryocyte, and whole blood specimens.

Sumanth Mosale SeetharamYi LiuJason WuLenn FechterKanagavel MurugesanHolden MaeckerJason GotlibJames ZehnderRamasamy Paulmurugan Anandi Krishnan

Published in: bioRxiv : the preprint server for biology (2023)

Enkurin, a calcium adaptor protein, is identified as a novel marker of pathogenesis in MPNs.MPN megakaryocyte and platelet expression of enkurin at RNA and protein levels is inversely associated with a cell differentiation cycle gene, CDC20.Likely role for dysregulated calcium homeostasis, and ER and protein folding stress in MPN transformation.

Keyphrases

protein protein
binding protein
poor prognosis
amino acid
small molecule
genome wide
single molecule
dna methylation
cell proliferation
molecular dynamics simulations
transcription factor
estrogen receptor
fine needle aspiration
breast cancer cells
ultrasound guided
nucleic acid
genome wide analysis