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MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes.

Shawn VeitchMakon-Sébastien NjockMark ChandyM Ahsan SirajLijun ChiHaoQi MakKai YuKumaragurubaran RathnakumarCarmina Anjelica Perez-RomeroZhiqi ChenFaisal J AlibhaiDakota GustafsonSneha RajuRuilin WuDorrin Zarrin KhatYaxu WangAmalia CaballeroPatrick MeagherEdward LauLejla PepicHenry S ChengNatalie J GalantKathryn L HoweRen-Ke LiKim A ConnellyMansoor HusainPaul Delgado-OlguinJason E Fish
Published in: Cardiovascular diabetology (2022)
MiR-30d/e represent early biomarkers and potential therapeutic targets that are indicative of the development of diastolic dysfunction and may reflect altered EC fatty acid metabolism and microvascular dysfunction in the diabetic heart.
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