MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes.

Shawn VeitchMakon-Sébastien NjockMark ChandyM Ahsan SirajLijun ChiHaoQi MakKai YuKumaragurubaran RathnakumarCarmina Anjelica Perez-RomeroZhiqi ChenFaisal J AlibhaiDakota GustafsonSneha RajuRuilin WuDorrin Zarrin KhatYaxu WangAmalia CaballeroPatrick MeagherEdward LauLejla PepicHenry S ChengNatalie J GalantKathryn L HoweRen-Ke LiKim A ConnellyMansoor HusainPaul Delgado-OlguinJason E Fish

Published in: Cardiovascular diabetology (2022)

MiR-30d/e represent early biomarkers and potential therapeutic targets that are indicative of the development of diastolic dysfunction and may reflect altered EC fatty acid metabolism and microvascular dysfunction in the diabetic heart.

Keyphrases

fatty acid
oxidative stress
cell proliferation
type diabetes
long non coding rna
cardiovascular disease
endothelial cells
coronary artery disease
heart failure
blood pressure
left ventricular
risk assessment
insulin resistance
skeletal muscle
glycemic control
aortic valve
ejection fraction