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Multi-omics integration reveals the oncogenic role of eccDNAs in diffuse large B-cell lymphoma through STING signalling.

Zijuan WuWei ZhangLuqiao WangJiayan LengYongle LiZhou FanMengtao ZhanLei CaoYongning JiangYan JiangBing SunJianxin FuJianyong LiWenyu ShiHui Jin
Published in: Clinical and translational medicine (2024)
EccDNAs induced by DNA damage exert an oncogenic role in DLBCL via activating the STING signalling independently of cGAS. The combined treatment of chemotherapeutic drugs with STING inhibitor significantly delayed the tumor progression, providing new insights into the therapeutic strategy for patients with DLBCL, particularly the relapsed and/or refractory (R/R) ones.
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