Transcriptional profiling of PPARα-/- and CREB3L3-/- livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα.

Philip M M RuppertJong-Gil ParkXu XuKyu Yeon HurAnn-Hwee LeeSander Kersten

Published in: BMC genomics (2019)

These data indicate that CREB3L3 ablation uncouples the hepatoproliferative and lipid metabolic effects of PPARα. Overall, except for the shared regulation of a very limited number of genes, the roles of PPARα and CREB3L3 in hepatic lipid metabolism are clearly distinct and are highly dependent on dietary status.

Keyphrases

fatty acid
insulin resistance
gene expression
transcription factor
genome wide
big data
electronic health record
metabolic syndrome
adipose tissue
machine learning
dna methylation
oxidative stress
atrial fibrillation
deep learning
artificial intelligence