Transposon insertion profiling by sequencing (TIPseq) identifies novel LINE-1 insertions in human sperm.

Thalita S Berteli Fang WangWilson McKerrowPaula Andrea NavarroDavid FenyoJef D BoekeFabiana Barzotto Kohlrausch David Lawrence Keefe

Published in: Journal of assisted reproduction and genetics (2023)

This study for the first time reports novel LINE-1 insertions in human sperm, demonstrating the feasibility of scTIPseq, and identifies new contributors to genetic diversity in the human germ line.

Keyphrases

endothelial cells
induced pluripotent stem cells
genetic diversity
pluripotent stem cells
genome wide
single cell
gene expression
emergency department
dna methylation