Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome.

Cesare CremonV StanghelliniM R BarbaroR F CogliandroL BellacosaJ SantosM VicarioM PigrauC Alonso CotonerB LoboFernando AzpirozS Bruley des VarannesM NeunlistD DeFilippisT IuvoneS PetrosinoV Di MarzoG Barbara

Published in: Alimentary pharmacology & therapeutics (2017)

The marked effect of the dietary supplement palmithoylethanolamide/polydatin on abdominal pain in patients with IBS suggests that this is a promising natural approach for pain management in this condition. Further studies are now required to elucidate the mechanism of action of palmithoylethanolamide/polydatin in IBS. ClinicalTrials.gov number, NCT01370720.

Keyphrases

irritable bowel syndrome
pain management
clinical trial
abdominal pain
open label
double blind
chronic pain
study protocol
phase ii
neuropathic pain
phase iii
randomized controlled trial
placebo controlled
anti inflammatory
case control
spinal cord injury