Therapeutic Effects of Green Tea Polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis.
Daniela MokraMarta JoskovaJuraj MokryPublished in: International journal of molecular sciences (2022)
(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea. Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways, and nuclear transcription factors, EGCG possesses a wide variety of anti-inflammatory, antioxidant, antifibrotic, anti-remodelation, and tissue-protective properties which may be useful in the treatment of various diseases, particularly in cancer, and neurological, cardiovascular, respiratory, and metabolic disorders. This article reviews current information on the biological effects of EGCG in the above-mentioned disorders in relation to molecular pathways controlling inflammation, oxidative stress, and cell apoptosis.
Keyphrases
- oxidative stress
- cell surface
- induced apoptosis
- anti inflammatory
- diabetic rats
- ischemia reperfusion injury
- dna damage
- transcription factor
- signaling pathway
- cell proliferation
- single molecule
- heat shock
- healthcare
- randomized controlled trial
- squamous cell
- epithelial mesenchymal transition
- combination therapy
- cell death
- pi k akt
- cell cycle arrest
- dna binding
- respiratory tract
- pulmonary fibrosis