A novel mathematical method for disclosing oscillations in gene transcription: A comparative study.

Athanasios C AntoulasBokai ZhuQiang ZhangBrian YorkBert W O'MalleyClifford C Dacso

Published in: PloS one (2018)

The pencil method provides new insights on the essence of gene expression and discloses a wide variety of oscillations in addition to the well-studied circadian pattern. This insight opens the door to the study of novel mechanisms by which oscillatory gene expression signals exert their regulatory effect on cells to influence human diseases.

Keyphrases

gene expression
dna methylation
induced apoptosis
working memory
endothelial cells
transcription factor
cell cycle arrest
genome wide
high frequency
copy number
signaling pathway
cell death
oxidative stress
pluripotent stem cells
cell proliferation