An integrated investigation of oocyte developmental competence: expression of key genes in human cumulus cells, morphokinetics of early divisions, blastulation, and euploidy.
Catello ScaricaD CimadomoL DovereA GiancaniM StoppaA CapalboF M UbaldiL RienziR CanipariPublished in: Journal of assisted reproduction and genetics (2019)
CAMK1D level of expression in CCs associated with blastocyst development. If confirmed from larger studies in wider populations of patients, the investigation of CC key gene expression might suit IVF clinics not adopting blastocyst culture. Future investigations should clarify the role of CAMK1D in ovarian physiology and could provide novel insights on how oocytes gain competence during folliculogenesis.
Keyphrases
- gene expression
- poor prognosis
- end stage renal disease
- induced apoptosis
- ejection fraction
- newly diagnosed
- endothelial cells
- chronic kidney disease
- primary care
- dna methylation
- prognostic factors
- cell cycle arrest
- binding protein
- genome wide
- cell death
- oxidative stress
- signaling pathway
- induced pluripotent stem cells
- patient reported outcomes
- patient reported
- endoplasmic reticulum stress
- genetic diversity