Cytoprotective Properties of Citronella Oil (Cymbopogon nardus (L.) Rendl.) and Lemongrass Oil (Cymbopogon citratus (DC.) Stapf) through Attenuation of Senescent-Induced Chemotherapeutic Agent Doxorubicin on Vero and NIH-3T3 Cells.
Dhiya Ulhaq SalsabilaRatih Kurnia WardaniNisa Ul HasanahAhmad Syauqy TafrihaniUmmi Maryam ZulfinMuthi' IkawatiEdy MeiyantoPublished in: Asian Pacific journal of cancer prevention : APJCP (2023)
The major marker components of CO and LO were citronellal and citral, respectively. Both oils showed low cytotoxic activity against Vero and NIH-3T3 cells, with IC50 values of over 40 µg/mL. LO exhibited higher antioxidant capacity than CO, but there was no effect on the intracellular ROS level of both oils on Vero and NIH-3T3 cells. However, CO and LO decreased cellular senescence induced by doxorubicin exposure on both cells, as well as suppressed MMP-2 expression. Conclusion: Both CO and LO decrease the cellular senescence and MMP-2 expression with less cytotoxic effects on normal cells independently from their antioxidant capacities. The results were expected to support the use of CO and LO as tissue protective and anti-aging agents in maintaining the body's cellular health against chemotherapeutics or cellular damaging agents.
Keyphrases
- induced apoptosis
- poor prognosis
- dna damage
- cell cycle arrest
- endothelial cells
- drug delivery
- oxidative stress
- cell death
- healthcare
- mental health
- public health
- cancer therapy
- signaling pathway
- reactive oxygen species
- cell migration
- risk assessment
- high glucose
- anti inflammatory
- immune response
- diabetic rats
- cell proliferation
- health information