Effects of thymosin β4-derived peptides on migration and invasion of ovarian cancer cells.

Hyung Joon YoonYoung Lim OhEun-Ji KoAhyun KangWan Kyu EoKi Hyung KimJi Young LeeAri KimSungwook ChunHongbae KimMee Sun OckHee Jae Cha

Published in: Genes & genomics (2021)

The Tβ4 peptide and all of its derived fragment peptides including those without an actin binding motif stimulate migration and invasion of SKOV3 ovarian cancer cells. All peptides significantly increased RACK-1 expression and cell proliferation of SKOV3 cells. These results suggest that Tβ4 stimulates migration and invasion of SKOV3 cells by stimulation of cell proliferation through up-regulation of RACK-1 protein.

Keyphrases

cell proliferation
induced apoptosis
cell cycle arrest
amino acid
poor prognosis
cell cycle
endoplasmic reticulum stress
cell death
protein protein
dna binding