Adaptive clinical trials in surgery: A scoping review of methodological and reporting quality.
Phillip StaibanoEmily OulousianTyler McKechnieAlex ThabaneSamuel LuoMichael K GuptaHan ZhangJesse D PasternakMichael AuSameer ParpiaJ E M Ted YoungMohit BhandariPublished in: PloS one (2024)
Surgical trialists should consider implementing adaptive components to help improve patient recruitment and reduce trial duration. Reporting of future adaptive trials must adhere to existing CONSORT ACE 2020 guidelines. Future research is needed to optimize standardization of adaptive methods across medicine and surgery.
Keyphrases
- clinical trial
- minimally invasive
- coronary artery bypass
- current status
- adverse drug
- surgical site infection
- study protocol
- quality improvement
- randomized controlled trial
- angiotensin ii
- coronary artery disease
- acute coronary syndrome
- percutaneous coronary intervention
- angiotensin converting enzyme
- electronic health record
- drug induced