Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes.

Jia-Lin SunMujia LiHuaqin SunZiyuan LinBing ShiZhong-Lin Jia

Published in: Journal of human genetics (2024)

Our findings highlight the significance of ZFP36L2 in the etiology of NSOC, supported by both human genetic association data and functional studies in zebrafish. These results pave the way for further exploration of targeted interventions for craniofacial malformations.

Keyphrases

endothelial cells
genome wide
copy number
intellectual disability
cancer therapy
gene expression
dna methylation
induced pluripotent stem cells
pluripotent stem cells