The dynamics of the inflammatory response during BBN-induced bladder carcinogenesis in mice.
Marina DegoricijaJelena Korac-PrlicKatarina VilovicTonci IvanisevicBenedikt HauptVinko PaladaMarina PetkovicIvana KaramanJanoš TerzićPublished in: Journal of translational medicine (2019)
Despite the recent advances in bladder cancer therapy which include the use of checkpoint inhibitors, the treatment options for patients with locally advanced and metastatic BC remain limited. BBN-induced BC in mice displays an immunological profile which shares similarities with human MIBC thus representing an optimal model for preclinical studies on immunomodulation in management of BC.
Keyphrases
- inflammatory response
- high glucose
- cancer therapy
- endothelial cells
- squamous cell carcinoma
- locally advanced
- diabetic rats
- spinal cord injury
- high fat diet induced
- dna damage
- small cell lung cancer
- drug induced
- type diabetes
- clinical trial
- drug delivery
- cell therapy
- oxidative stress
- cell cycle
- radiation therapy
- metabolic syndrome
- mesenchymal stem cells
- lps induced
- insulin resistance
- adipose tissue
- case control
- induced pluripotent stem cells
- pluripotent stem cells