Ru(II)-Catalyzed Regioselective Hydroxymethylation of β-Carbolines and Isoquinolines via C-H Functionalization: Probing the Mechanism by Online ESI-MS/MS Screening.
Nagula ShankaraiahDarshana BoraSravani SanaFabiane M NachtigallLeonardo S SantosNagula ShankaraiahPublished in: The Journal of organic chemistry (2019)
A Ru(II)-catalyzed regioselective C-H activation toward hydroxymethylation of β-carbolines and isoquinolines as effective directing groups has been developed, and the mechanism was probed by using online electrospray ionization-tandem mass spectrometry. The introduction of the hydroxymethyl group in the biologically relevant molecules routed via C-H functionalization remains an important task. Gratifyingly, this protocol draws attention to the regioselective formation of monohydroxymethylated β-carboline/isoquinoline products exclusively.
Keyphrases
- ms ms
- tandem mass spectrometry
- ultra high performance liquid chromatography
- high performance liquid chromatography
- liquid chromatography
- simultaneous determination
- gas chromatography
- social media
- room temperature
- health information
- liquid chromatography tandem mass spectrometry
- molecular dynamics simulations
- solid phase extraction
- high resolution
- energy transfer
- mass spectrometry
- working memory
- high resolution mass spectrometry
- randomized controlled trial
- single molecule
- healthcare
- ionic liquid