Combining Homologous Recombination-Deficient Testing and Functional RAD51 Analysis Enhances the Prediction of Poly(ADP-Ribose) Polymerase Inhibitor Sensitivity.
Lea Milling KorsholmMaj KjeldsenLorenzo PerinoLuca MarianiGitte-Bettina NyvangElisabeth KristensenFrederik Otzen BaggerMansoor Raza MirzaMaria RossingPublished in: JCO precision oncology (2024)
The robust concordance between the open standard LDT and the CDx, especially the correlation with PFS, warrants future validation and implementation of the open standard LDT for HRD testing in diagnostic settings.