Association of Blood Concentrations of Complement Split Product iC3b and Serum C3 With Systemic Lupus Erythematosus Disease Activity.
Alfred Hyoungju KimVibeke StrandDeepali P SenQiang FuNancy L MathisMartin J SchmidtRobin R BruchasNick R StatenPaul K OlsonChad M StieningJohn P AtkinsonPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2019)
The ratio of blood iC3b to serum C3 concentrations correlates with the extent of SLE disease activity and with clinically meaningful changes in disease activity in patients with SLE. Furthermore, the iC3b:C3 ratio may discriminate between active and inactive SLE, and between major flares and no active disease.