Synthesis of Water-Dispersible Mn2+ Functionalized Silicon Nanoparticles under Room Temperature and Atmospheric Pressure for Fluorescence and Magnetic Resonance Dual-Modality Imaging.
Ya-Kun DouYang ChenXi-Wen HeWen-You LiYu-Hao LiYu-Kui ZhangPublished in: Analytical chemistry (2017)
Silicon nanoparticles (Si NPs) have been widely used in fluorescence imaging. However, rigorous synthesis conditions and the single modality imaging limit the further development of Si NPs in the field of biomedical imaging. Here, we reported a method for synthesizing water-dispersible Mn2+ functionalized Si NPs (Mn-Si NPs) under mild experimental conditions for fluorescence and magnetic resonance dual-modality imaging. The whole synthesis process was completed under room temperature and atmospheric pressure, and no special and expensive equipment was required. The synthetic nanoparticles, with favorable pH stability, NaCl stability, photostability, and low toxicity, emitted green fluorescence (512 nm). At the same time, the nanoparticles also demonstrated excellent magnetic resonance imaging ability. In vitro, their T1-weighted magnetic resonance imaging effect was obvious, and the value of longitudinal relaxation degree r1 reached 4.25 mM-1 s-1. On the basis of their good biocompatibility, Mn-Si NPs were successfully used for the fluorescence imaging as well as magnetic resonance imaging in vivo.
Keyphrases
- room temperature
- fluorescence imaging
- magnetic resonance imaging
- magnetic resonance
- ionic liquid
- photodynamic therapy
- high resolution
- contrast enhanced
- single molecule
- computed tomography
- oxide nanoparticles
- oxidative stress
- particulate matter
- cross sectional
- air pollution
- simultaneous determination
- network analysis