Differential Role of mGluR5 in Cognitive Processes in Posttraumatic Stress Disorder and Major Depression.

Irina EsterlisSarah DeBoneeRyan CoolSophie HolmesStephen R BaldassariPaul MaruffRobert H PietrzakMargaret T Davis

Published in: Chronic stress (Thousand Oaks, Calif.) (2022)

We observed a significant relationship between frontolimbic mGluR5 availability and performance on tests of attention in individuals with MDD and PTSD. This finding aligns with animal work showing dysregulation in mGluR5 in cognitive functioning, and differed as a function of diagnosis. Results suggest interventions targeting mGluR5 may help bolster cognitive difficulties, highlighting the importance of employing different mGluR5 directed treatment strategies in MDD and PTSD.

Keyphrases

posttraumatic stress disorder
major depressive disorder
physical activity
social support
cancer therapy
bipolar disorder
drug delivery