Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis".

Arturo Álvarez-Buylla Arantxa Cebrian-Silla Shawn F Sorrells Marcos Assis Nascimento Mercedes F Paredes Jose Manuel García-Verdugo Zhengang Yang Eric J Huang

Published in: Science (New York, N.Y.) (2022)

Terreros-Roncal et al . investigated the impacts of human neurodegeneration on immunostainings assumed to be associated with neurogenesis. However, the study provides no evidence that putative proliferating cells are linked to neurogenesis, that multipolar nestin + astrocytes are progenitors, or that mature-looking doublecortin + neurons are adult-born. Their histology-marker expression differs from what is observed in species where adult hippocampal neurogenesis is well documented.

Keyphrases

cerebral ischemia
endothelial cells
neural stem cells
induced pluripotent stem cells
subarachnoid hemorrhage
induced apoptosis
poor prognosis
brain injury
cell cycle arrest
childhood cancer
young adults
cell death
preterm infants
temporal lobe epilepsy
single molecule
preterm birth
pi k akt