Deep phenotyping of the lipidomic response in COVID-19 and non-COVID-19 sepsis.
Hu MengArjun SenguptaEmanuela RicciottiAntonijo MrčelaDivij MathewLiudmila L MazaleuskayaSoumita GhoshThomas G BrooksAlexandra P TurnerAlessa Soares SchanoskiNicholas F LahensAi Wen TanAshley WoolforkGreg GrantKatalin SusztakAndrew G LetiziaStuart C SealfonE John WherryKrzysztof LaudanskiAalim M WeljieNuala J MeyerGarret A FitzGeraldPublished in: Clinical and translational medicine (2023)
A broad based lipidomic storm is a predictor of poor prognosis in ARDS. Alterations in sPLA2, PGD2 and 12-HETE and the high abundance lipids, ChoE 18:3, LPC-O-16:0 and PC-O-30:0 exhibit relative specificity for COVID-19 amongst such patients and correlate with the inflammatory response to link to disease severity.
Keyphrases
- coronavirus disease
- poor prognosis
- sars cov
- end stage renal disease
- long non coding rna
- newly diagnosed
- ejection fraction
- chronic kidney disease
- intensive care unit
- acute respiratory distress syndrome
- oxidative stress
- prognostic factors
- acute kidney injury
- peritoneal dialysis
- high throughput
- mechanical ventilation
- patient reported outcomes
- single cell
- microbial community
- septic shock