Effect of Intralipid infusion on peripheral blood T cells and plasma cytokines in women undergoing assisted reproduction treatment.
Kerrie L FoyleDavid J SharkeyLachlan M MoldenhauerElla S GreenJasmine J WilsonCassandra J RoccisanoMary Louise HullKelton P TremellenSarah A RobertsonPublished in: Clinical & translational immunology (2021)
Intralipid infusion elicited elevated pro-inflammatory cytokines, and a minor increase in CD8+ T cells, but no change in pro-tolerogenic Treg cells. Notwithstanding the limitation of no placebo control, the results do not support Intralipid as a candidate intervention to attenuate the Treg cell response in women undergoing ART. Future placebo-controlled studies are needed to confirm the potential efficacy and clinical significance of Intralipid in attenuating cytokine induction and circulating CD8+ T cells.
Keyphrases
- peripheral blood
- polycystic ovary syndrome
- placebo controlled
- double blind
- low dose
- induced apoptosis
- randomized controlled trial
- dendritic cells
- pregnancy outcomes
- anti inflammatory
- cell cycle arrest
- single cell
- regulatory t cells
- cell therapy
- current status
- breast cancer risk
- type diabetes
- hiv infected
- phase iii
- clinical trial
- squamous cell carcinoma
- stem cells
- immune response
- open label
- risk assessment
- adipose tissue
- combination therapy
- signaling pathway
- cell proliferation
- human health
- replacement therapy
- phase ii study
- pi k akt
- case control