While climate models and observations generally agree that climate feedbacks collectively amplify the surface temperature response to radiative forcing, the strength of the feedback estimates varies greatly, resulting in appreciable uncertainty in equilibrium climate sensitivity. Because climate feedbacks respond differently to different spatial variations in temperature, short-term observational records have thus far only provided a weak constraint for climate feedbacks operating under global warming. Further complicating matters is the likelihood of considerable time variation in the effective global climate feedback parameter under transient warming. There is a need to continue to revisit the underlying assumptions used in the traditional forcing-feedback framework, with an emphasis on how climate models and observations can best be utilized to reduce the uncertainties. Model simulations can also guide observational requirements and provide insight on how the observational record can most effectively be analyzed in order to make progress in this critical area of climate research.