Immunohistochemical Expression of Claudin-1 and Claudin-4 in Urothelial Carcinoma of the Urinary Bladder.

Aya Magdy ElsayedEman Ibrahim MahmoudMostafa Mohamed SalemRasha Ahmed Khairy

Published in: Asian Pacific journal of cancer prevention : APJCP (2024)

According to the results ofthe present study, the reduced expressions of Claudin-1 and Claudin-4 provide clues concerning the progression of urothelial carcinoma. Consequently, it is thought that Claudin-1 and Claudin-4 could help to differentiatelow-grade from high-grade and muscle-invasive from non-muscle-invasive urothelial carcinomas. In addition, it can be introduced as a possible therapeutic target.

Keyphrases

high grade
skeletal muscle
low grade
poor prognosis
binding protein