Expression analysis of extracellular microRNA in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis.
Amit KishoreZdenka NavratilovaVitezslav KolekEva NovosadovaKlára ČépeRoland M du BoisMartin PetrekPublished in: Respirology (Carlton, Vic.) (2018)
Our data provide evidence that exosomes and microvesicles as extracellular vesicles are present in the bronchoalveolar space of sarcoidosis patients and they differentially express EV miRNA (miR-146a and miR-150), the expression of which correlates negatively with pulmonary function indices. The significance of these findings for disease pathophysiology and clinical course require further investigation.
Keyphrases
- cell proliferation
- long non coding rna
- end stage renal disease
- poor prognosis
- ejection fraction
- long noncoding rna
- newly diagnosed
- chronic kidney disease
- stem cells
- mesenchymal stem cells
- pulmonary hypertension
- prognostic factors
- peritoneal dialysis
- machine learning
- patient reported outcomes
- patient reported
- deep learning