The Effect of Irisin on Human Nucleus Pulposus Cells: New Insights into the Biological Crosstalk between the Muscle and Intervertebral Disc.

Gianluca VadalàGiuseppina Di GiacomoLuca AmbrosioClaudia CicioneVeronica TilottaFabrizio RussoRocco PapaliaVincenzo Denaro

Published in: Spine (2022)

Irisin increases hNPC proliferation, GAG content, metabolic activity and promotes anabolic gene expression while reducing catabolic markers. Irisin may be one of the mediators by which PE and muscle tissues modulate IVD metabolism, suggesting the existence of a biological crosstalk between the muscle and IVD.

Keyphrases

gene expression
skeletal muscle
induced apoptosis
endothelial cells
signaling pathway
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
cell death
pluripotent stem cells
pi k akt