Overexpression of miR-506-3p Aggravates DBP-Induced Testicular Oxidative Stress in Rats by Downregulating ANXA5 via Nrf2/HO-1 Signaling Pathway.
Min TangLei ZhangZheng ZhuRan LiShangqian WangWei WangZhiqiang QinWei ZhangPublished in: Oxidative medicine and cellular longevity (2020)
This study provided evidence that miR-506-3p could aggravate the DBP-treated testicular oxidative stress injury in vivo and in vitro by inhibiting ANXA5 expression and downregulating Nrf2/HO-1 signaling pathway, which might provide novel understanding in DBP-induced testicular injury therapy.
Keyphrases
- oxidative stress
- diabetic rats
- signaling pathway
- pi k akt
- induced apoptosis
- germ cell
- high glucose
- ischemia reperfusion injury
- dna damage
- poor prognosis
- epithelial mesenchymal transition
- drug induced
- endothelial cells
- stem cells
- long non coding rna
- endoplasmic reticulum stress
- mesenchymal stem cells
- binding protein
- stress induced
- heat shock protein