Phase 1/2 Trial of Vorinostat and Radiation and Maintenance Vorinostat in Children with Diffuse Intrinsic Pontine Glioma: A Children's Oncology Group Report.

Jack M SuLindsay B KilburnDavid B MansurMark KrailoAllen BuxtonAdesina AdekunleAmar GajjarPeter C AdamsonBrenda WeigelElizabeth FoxSusan M BlaneyMaryam Fouladi

Published in: Neuro-oncology (2021)

Vorinostat given concurrently with radiation followed by vorinostat monotherapy was well tolerated in children with newly-diagnosed DIPG but failed to improve outcome.

Keyphrases

young adults
newly diagnosed
histone deacetylase
palliative care
randomized controlled trial
clinical trial
open label
radiation therapy
radiation induced
study protocol