Identification of three novel DNMT3A mutations with compromising methylation capacity in human acute myeloid leukaemia.
Ayad M AliGaza F SalihPublished in: Molecular biology reports (2022)
Our findings highlight the importance of studying the effects of DNMT3A methylation alteration in Iraqi populations beyond R882 substitutions in the leukemogenic pathway so that patient treatment can be tailored to prevent therapeutic resistance and relapse.
Keyphrases
- dna methylation
- genome wide
- endothelial cells
- liver failure
- gene expression
- case report
- bone marrow
- dendritic cells
- acute myeloid leukemia
- induced pluripotent stem cells
- pluripotent stem cells
- smoking cessation
- drug induced
- immune response
- free survival
- hepatitis b virus
- aortic dissection
- combination therapy
- extracorporeal membrane oxygenation