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Markov State Models and Perturbation-Based Approaches Reveal Distinct Dynamic Signatures and Hidden Allosteric Pockets in the Emerging SARS-Cov-2 Spike Omicron Variants Complexes with the Host Receptor: The Interplay of Dynamics and Convergent Evolution Modulates Allostery and Functional Mechanisms.

Sian XiaoMohammed AlshahraniGrace GuptaPeng TaoGennady M Verkhivker
Published in: bioRxiv : the preprint server for biology (2023)
Keyphrases
  • sars cov
  • genome wide
  • copy number
  • small molecule
  • respiratory syndrome coronavirus
  • single cell
  • binding protein
  • coronavirus disease