HIV-1 subtype C predicted co-receptor tropism in Africa: an individual sequence level meta-analysis.
Nontokozo D MatumeDenis M TebitPascal Obong BessongPublished in: AIDS research and therapy (2020)
Our analyses illustrate that X4 viruses are present in significantly similar proportions in early and early chronic HIV-1 subtype C infected individuals across Africa. In contrast, in late chronic infections, X4 viruses increase 3-5 folds. We can draw two inferences from our observations: (1) to enhance the utility of Maraviroc in chronic HIV subtype C infections in Africa, prior virus co-receptor determination is needed; (2) on the flip side, research on the efficacy of CXCR4 antagonists for HIV-1-C infections is encouraged. Currently, the use of Maraviroc is very limited in Africa.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- men who have sex with men
- systematic review
- south africa
- magnetic resonance
- randomized controlled trial
- magnetic resonance imaging
- drug induced
- mass spectrometry
- cell migration
- liquid chromatography
- tandem mass spectrometry